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So when someone says, GLP-1s cause muscle loss, the first question should be: what exactly was measured

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The molecule is classified as a triple receptor agonist because it interacts with three endocrine receptors involved in metabolic regulation: the glucagon-like peptide-1 receptor (GLP-1R), the glucose-dependent insulinotropic polypeptide receptor (GIPR), and the glucagon receptor (GCGR)

The highest dose led to 23.7% average weight loss at 68 weeks when including all participants and 28.7% among those who completed treatment.