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The most common side effects were mild to moderate gastrointestinal symptoms, such as nausea and vomiting, primarily associated with the first dose and substantially reduced with dose escalation

Indeed, GLP-1R activation induces FGF21 production [[31], [32], [33], [34], [35], [36]]

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[DOI] [PMC free article] [PubMed] [Google Scholar] 44.Stein KB Snyder CF, Barone BB, Yeh H-C, Peairs KS, Derr RL, Wolff AC, Brancati FL

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The manufacturers of these drugs have priced them at more than $1,000 per month, and limited competition in the space is putting them out of reach for many patients and creating financial burden on healthcare systems
