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Serious hypersensitivity reactions such as anaphylaxis and angioedema have occurred with these drugs

Lv YQ, Yuan L, Sun Y, Dou HW, Su JH, Hou ZP, et al

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doi:10.1124/molpharm.121.000270 3

In a separate 2 year double blinded, placebo-controlled study, weekly subcutaneous injections of semaglutide (2.4mg) in obese patients, average body weights decreased 12.6% over placebo at the 2-year point [23]
However, considerations around kidney function monitoring, hydration status, and body composition tracking warrant careful clinical evaluation when using both concurrently
