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Several multi-targeting agonists at GIPR, GLP-1R or GCGR, developed to maximize metabolic benefits with reduced side-effects, are in clinical trials to treat type 2 diabetes and obesity

Regarding adverse events, one thing stands out is dysesthesia which occurred in 8.8% and 20.9% (9 mg and 12 mg, respectively) of patients, compared to 0.7% with placebo

For example, in a mid-stage human study, people taking higher doses (up to 12mg) lost an average of 24% of their body weight over 48 weeks, which is about 58 pounds for some