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Frequently Asked Questions Will semaglutide actually reduce my hot flashes, or is it just the weight loss

Genetics plays a role here, and people who have genetically lower IgE levels are less likely to have chronic urticaria.[ref] Mast cells, atrial fibrillation, and cardiac diseases: Researchers estimate that there are ~50,000 mast cells/g of human heart tissue
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Gradual dose increases help minimize these effects.

30 Although a causal relationship has not been established, patients should be instructed to pay close attention for symptoms of ketoacidosis (e.g., difficulty breathing, vomiting, confusion, unusual fatigue or sleepiness) and to seek immediate medical attention if any of these occur

This medical supervision protects patient safety but requires appointments, copays, and ongoing healthcare system engagement
