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water for injection (WFI), sterile water solution, or bacteriostatic water for injection (BWFI) may be used

Adding GIP (the tirzepatide model) deepens the effect and, somewhat counterintuitively, appears to improve gastrointestinal tolerability relative to GLP-1 alone

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Capristo E, Panunzi S, De Gaetano A, Raffaelli M, Guidone C, Iaconelli A, et al

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The 2025 rat study on fibromyalgia [2], the 2026 OA cartilage data [12], the ACR 2025 rheumatic disease findings [11], and the growing body of neurobiological research all point in the same direction