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AAV Mediated Exendin-4 Gene Transfer to Salivary Glands to Protect Subjects from Diabetes or Obesity

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Experts say supporting gut and heart health, preserving muscle, and protecting bone are essential for long-term success

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No patients receiving GLP-1 RAs were excluded due to loss of follow-up, while 8 patients (0.2%) who did not receive GLP-1 RAs were excluded for this reason (Supplemental Table 3)

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Procedures such as gastric bypass or sleeve gastrectomy typically result in 25-30% total body weight loss and often lead to diabetes remission

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Their motivations can vary, driven by concerns such as health (50%), appearance (35%) or mood (15%).17 As a result, they may not perceive their need as strictly medical and so may be put off by products with overtly medical aesthetics

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Acknowledgements We thank all the participants, investigators, and trial-site staff who were involved in the conduct of these trials

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