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however, their role may be more pharmacological than physiological

On average, patients treated with exenatide lost 5.4 kg more weight compared to those treated with biphasic insulin aspart [58]

Under cholesterol stimulation, GLP-1-induced AMPK activation inhibited PARP-1 activity, therefore attenuating cholesterol-induced toxicity in INS-1 cells

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However, in the CV safety outcome trials, a numerical imbalance in adjudicated cases of acute pancreatitis was noted (124127, 129, 130), although the absolute risk was still very low
