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This in turn reduces the amount of insulin the body needs, ultimately resulting in reduced hyperglycemia and improved control of glucose levels
[49] further noted that GLP1R is widely expressed in retinal endothelial cells, and its activation significantly inhibits the expression and secretion of multiple inflammatory factors such as TNF- and IL1, reducing immune cell infiltration

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Retatrutide typically comes as a lyophilized (freeze-dried) powder that must be reconstituted with bacteriostatic water before use

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Endocrinology 153: 30543065