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[46] Concurrently, semaglutide inhibits the release of glucagon from pancreatic alpha cell, which decreases glucose production by the liver (gluconeogenesis) and maintains blood sugar level stability, particularly preventing sharp spikes after meals

There are also data that suggest that bile acid malabsorption can be successfully treated with GLP-1RA 103 and this may be an important confounder in registry studies that was not corrected for