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Description
See Figure 1: Mechanisms of GLP-1 Receptor Agonists

Originally developed to help treat type 2 diabetes, GLP-1 drugs have proven effective at promoting weight loss , at least for as long as the medications remain in use

This thrust will put Merck in direct competition with obesity frontrunners Eli Lilly and Novo Nordisk, which are both advancing their respective oral GLP-1 candidates

It follows Ro's announcement in April of NBA legend Charles Barkley joining as their first GLP-1 celebrity patient ambassador

However, cagrilinitide, exenatide, and orforglipron did not exhibit a significant increase in constipation risk

The data is less clear but increasingly supportive that some patients can space out their injections or step down to lower doses while maintaining their loss
