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Observational studies and clinical trials provide insight into this concern

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Apply gentle pressure with clean gauze if bleeding occurs, but avoid rubbing the area

Despite the work being focused on diabetic rats and no anti-obesogenic assays being performed, metformin has proved to have anti-obesogenic effects, and therefore, this approach has a great potential for obesity treatment (Feng et al., 2022)

If nausea is new or significantly worse than expected, consider whether it could represent lupus GI involvement rather than a simple medication side effect

This comparison highlights the importance of choosing a medication with proven safety during pregnancy