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According to NICE guidance (NG28), patients on GLP-1 receptor agonists should be reviewed regularly, with continuation based on specific HbA1c reduction and weight loss targets at around 6 months of treatment

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208 Insulin-like growth factor binding proteins 1 and 2 (IGFBP1 and IGFBP2, respectively) are the most abundant circulating IGFBPs and have lower concentrations in adipose tissue in obese patients, in addition to being negatively associated with hyperinsulinemia and IR

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