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N Engl J Med 375:311322 Hollander P, Gupta AK, Plodkowski R et al (2013) Effects of naltrexone sustained-release/bupropion sustained-release combination therapy on body weight and glycemic parameters in overweight and obese patients with type 2 diabetes

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Additional benefits include improvement in blood pressure, lipid levels, and inflammatory markers, with potential benefit in NAFLD

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The why behind the study must dictate the how long

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Better weight control often means better insulin sensitivity, improved blood sugar management, and potentially slower progression of Type 2 diabetes

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