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Mutating more than one allele of LRP5 is associated with serious consequences, while heterozygous loss-of-function variations may result in milder manifestations of the condition (Liu J

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This risk is higher in people who have heavy periods or severe cramps

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remain upright for at least 23 hours post-meal Stay well hydrated with small, frequent sips of water throughout the day, but avoid drinking large volumes with meals Timing considerations may help some patients