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Over 36 months, estimated glomerular filtration rate (eGFR) declined by just 3.0 mL/min per 1.73m2 with tirzepatide versus 7.2 mL/min per 1.73m2 with dulaglutide
And that number could just continue to rise as more drugs come onto the market

Always seek medical advice and read prescribing information or Medication Guides
doi: 10.1517/14656566.2014.965678 [DOI] [PubMed] [Google Scholar] 58

However, most of the research conducted on the species has involved its role in pathogenesis, not as a microbial therapeutic

Nausea is most often reported by patients, and vomiting, diarrhea, abdominal pain, and/or constipation have also been documented
