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While synthetic GLP-1 receptor agonists (RAs) like semaglutide and tirzepatide dominate clinical use, plant-derived GLP-1 modulators present a promising alternative due to their natural origin, diverse mechanisms, and potential for reduced side effects

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From cardiovascular protection and kidney benefits to neurodegenerative and liver disease potential, this article covers the expanding therapeutic horizon of GLP-1R beyond diabetes and obesity.

Considering the central role of glucose catabolism for stimulus-secretion coupling in -cells, our findings suggest that chronic GLP-1 actions on insulin secretion include elevated -cell glucose metabolism

June 9, 2025

Heightened susceptibility of females to the aversive effects of GLP1R agonists could therefore involve increased activation of these brain circuits