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Dose titration follows the standard schedule

Concurrent lifestyle modificationsincluding caloric restriction, increased physical activity, and behavioral interventionssubstantially enhance both weight loss and metabolic outcomes

Prescribers often use the brand tirzepatide label as a reference point: 2.5 mg once weekly for 4 weeks as a tolerance dose, then 5 mg

They must be refrigerated prior to use and can only stay out of the fridge for a limited period and under specific conditions

The dietary-stimulated levels of GLP-1 are reduced in T2DM, whereas the insulinotropic effects after infusion of pharmacological levels of GLP-1 are similar in people with diabetes and those who are euglycemic [17,18]

While this is often a positive health development, it can be a surprise for those who have gone months or years without a predictable period