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These findings all indicate that GLP-1-induced ABCA1 upregulation contributes to the cholesterol homeostasis in pancreatic -cells and protects pancreatic -cells from cholesterol-induced toxicity

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Findings Suggest Drug Has the Potential To Reduce the Risk of Heart Disease, Diabetes, and Stroke In adults with obesity or overweight, weekly treatment with the glucagon-like peptide 1 (GLP1) receptor agonist semaglutide leads to reduced excess body fat and increased lean body mass, according to an industry-sponsored study presented virtually at ENDO 2021, the Endocrine Societys annual meeting

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