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[DOI] [PMC free article] [PubMed] [Google Scholar] 26.Aronne LJ, Horn DB, le Roux CW, et al

You start low and increase every four weeks to minimize side effects, particularly nausea, which is the most commonly reported gastrointestinal response

Competing interests MAN has been member on advisory boards or has consulted with Boehringer Ingelheim, Eli Lilly & Co., Menarini/Berlin Chemie, Merck, Sharp & Dohme, NovoNordisk, Regor, and ShouTi Inc./Gasherbrum

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However, benchmarking against SUSTAIN-6 flagged disagreement for the effect on all-cause mortality, highlighting potential residual confounding for this secondary endpoint that could reflect preferential prescribing in patients for whom clinicians anticipated limited life expectancy