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This finding makes sense because the magnitude of weight loss directly correlates with reduced mechanical stress on weight-bearing joints

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In addition, rapid weight loss may also transiently alter chemistry in some people, potentially increasing the risk of stone formation during periods of active weight reduction

Some of these issues are connected to the amino acid makeup of the drug

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Drug Des Devel Ther 19:56455652 Wang Y, Lan B, Zhang S, Mu Y, Mi J, Yu J et al (2025) Dionysus or apollo, skeletal muscle mass changes in type 2 diabetes with sarcopenia receiving GLP-1 receptor agonist: systematic review and meta-analysis