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While often associated with strength and power, creatine also plays a meaningful role in glucose handling and muscle-driven metabolism, both of which are tightly connected to GLP-1 activity

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10.1016/j.cmet.2017.02.008 205

Severe Fatigue Despite Normal Glucose: Although fatigue can be a side effect of rapid weight loss or initial GLP-1 therapy, if it persists and is accompanied by other symptoms, it warrants a TSH check to rule out hypothyroid symptoms that might be masked