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Reported side effects include: Headaches and irritability Fatigue or restlessness Fluid retention (edema) Enlarged breasts in men (gynecomastia) Increased risk of blood clots Interaction Concerns When taken together, the most significant risk is extreme fatigue and brain fog. If semaglutide makes you feel full and HCG is used alongside a 500-calorie diet, your body may not receive enough energy to function properly

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This mechanism may influence nutrient absorption, including iodine, which is critical for thyroid hormone synthesis

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