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Retatrutide is an investigational triple agonist targeting GLP-1, GIP, and glucagon receptors it is not yet approved by the MHRA or EMA

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Even among those who switched between GLP-1s, persistence was only 36%

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Reduced likelihood of weight regain with medical support

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A phased rollout is expected to extend eligibility progressively through June 2026 and March 2027

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An acetate-specific GPCR, FFAR2, regulates insulin secretion

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The challenge with combining retatrutide with other GLP-1-active compounds is receptor overlap

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