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Research on similar medications like Mounjaro (tirzepatide) has already shown that dual agonists can preserve muscle better than single agonists, and the addition of the glucagon receptor in retatrutide may push this advantage even further

This leads to lipid peroxidation, protein oxidation, and DNA damage, contributing to neuronal injury

J Clin Endocrinol Metab, 86:245-250

This is supported by the ADA Standards of Care in Diabetes

A study presented at ENDO 2025 found that people taking semaglutide who consumed higher amounts of protein lost significantly less muscle mass than those who did not prioritize their nutrition

Exercise Prescription: Regular exercise is vital for weight loss and maintaining a healthy weight