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You are adding a full new dose on top of a higher-than-expected residual amount
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Tirzepatide should be discontinued promptly if pancreatitis is suspected and not restarted if pancreatitis is confirmed

These medications may cause side effects, some of which can be serious (such as the potential risk of thyroid C-cell tumors)

Immune response to the drug, known as antibody formation, may alter effectiveness or tolerability in some users

In SURMOUNT-1 (NEJM 2022, 2,539 adults with obesity), the 15 mg arm averaged 22.5% body weight loss at 72 weeks, the 10 mg arm 21.4%, and the 5 mg arm 16.0%
