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Why have GLP-1 receptors historically been difficult to target with small molecules, and what has changed to make oral versions possible now

doi: 10.1111/bph.15508 71

[DOI] [PubMed] [Google Scholar] Tang-Christensen M, Vrang N, Larsen PJ

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Dose-Dependency: As suggested by the authors of the report and seen in Case 2, this adverse reaction appears to be dose-dependent , emerging at higher therapeutic doses