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What stood out: CagriSema achieved 23.0% weight loss at 84 weeks (efficacy estimand) Tirzepatide achieved 25.5% On the treatment-regimen estimand, weight loss was 20.2% vs 23.6% Primary endpoint not met: CagriSema did not demonstrate non-inferiority vs tirzepatide on weight loss at 84 weeks Why this matters This is a reminder that in obesity pharmacotherapy, very effective and best-in-class are not the same conversation

Semaglutide may be used alone or with other medications

However, due to rapid degradation by DPP-4, GLP-1/2 and GIP have short half-lives, with 1-2 minutes for GLP-1/2 and 7 minutes for GIP (18, 41)

However, it was not derived from patient focus groups nor was it initially designed to quantify pain, which has limited its application in some settings

This is important for people with diabetes because it helps keep blood sugar levels stable

Goal weight is 115-120