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It comes down to personal preference

It does not rely on the cytochrome P450 enzyme system in the liver, which is where many drug-drug interactions occur

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However, vigorous exercise close to bedtime may have a stimulating effect, so its best to schedule exercise sessions earlier in the day

(06:05): So I always say, no one made Rich do 5Ks and 10Ks

Also, some may feel side effects mainly when increasing a dosage, and then have those side effects gradually decrease as the body gets used to that amount