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Different pathways, different mechanisms, and often, a different type of ideal candidate

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In vitro studies have identified several peptide hormones and chemokines that are prone to degradation by DPP4 when exposed to high concentrations of the enzyme [124, 137]

Managing the Transition Period After Stopping Gradual dose reduction rather than abrupt discontinuation may help reduce rebound GI symptoms in some patients, though clinical guidance on tapering is still evolving

Staying hydrated is important