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A previous CB1 receptor blocker, Rimonabant, was approved in Europe in 2006 but was discontinued in 2008 owing to serious psychiatric side effects
Obesity is on the rise, with rapidly rising rates among adults, adolescents, and children
Obesity is prevalent, affecting 40% of Americans age 20-plus and costing the economy nearly $1.4 trillion a year
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Indeed, a cluster of molecules related to the serotonergic system has been reported to influence serotonin levels and host metabolism (Table 2)
GLP-1 may downregulate miR-27a via activating AMPK
