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Additionally, lipotoxicity from excess free fatty acids generates diacylglycerols and ceramides, which activate protein kinase C isoforms and impair insulin receptor (IR) and IRS function through serine phosphorylation (62)
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Thyroid function should be monitored more frequently in autoimmune thyroid patients taking tirzepatide, and any new thyroid nodules or changes in thyroid function should be investigated promptly
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