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Henney 2024) demonstrated a potentially meaningful reduction in incident pneumonia with GLP-1 RAs compared with dipeptidyl peptidase-4 (DPP-4) inhibitors (hazard ratio [HR] 0.60, 95% confidence interval [CI] 0.580.62
These medications are everywhere right nowon the news, in gym conversations, and even debated in doctors offices
A number of investigational new drugs targeting GLP-1R, GIPR and GDF-8 pathways are under clinical trials (Table 2)
Retatrutide is gaining attention in the GLP-1 conversation
Taken together, these patterns suggest that GLP-1 adoption is not only transforming diabetes and obesity care but also influencing prescribing behavior and patient management across a broader set of comorbid markets
Their dual mechanism may address key limitations of current pharmacotherapies
