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Most semaglutide users experience nausea and digestive changes that peak within the first 2-4 weeks, then gradually improve over 8-12 weeks as the body adapts to the medication

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Chronic knockdown of LH GLP-1R induced by intraparenchymal delivery of an adeno-associated virus-short hairpin RNA construct was sufficient to markedly and persistently elevate ingestive behavior and body weight and ultimately resulted in a doubling of fat mass in males and females