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This aligns with the hypothesis that greater weight loss leads to superior cardiovascular benefits, reinforcing the potential of Tirzepatide in hypertensive patients with obesity

However, because glucagon-like peptide-1 receptor agonists work to slow gastric emptying, a safety concern has been raised in patients undergoing deep sedation or general anesthesia regarding gastric aspiration, and considering their long half-life in the blood, they are difficult to manage in the perioperative period

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