surmount-1 trial tirzepatide non-diabetic weight loss For the first time, and semaglutide were put in the same trial. SURMOUNT-5. Phase 3b RCT. 751 adults with obesity, no diabetes. 72 weeks. Both drugs at maximum tolerated dose. The Tirzepatide and blood pressure reduction:
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These effects typically diminish with continued use and can be minimized through gradual dose titration and administration with meals
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