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Furthermore, the -helical ECL3 moves toward the TMD core by 12.3 in the inactive GLP-1R structure (measured at C of T378)

The aim of the work was to analyse the occurrence, processing pattern and secretion of glucagon-like peptides from the pancreas and gut (Holst 2019)

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Specifically, in the extracellular half of GLP-2R, TM1 forms at least one additional helical turn, thereby moving toward TM2 (5 , measured by C of the residue at 1.33b) and bending down toward GLP-2

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