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GLP-1 as a Longevity / Systems Platform EVIDENCE TIER, MULTI-OMIC ASSOCIATION + EDITORIAL POSITION In April 2026, Cell Metabolism published a multi-omic analysis of GLP-1 receptor agonist effects across organ systems that, in the careful language scientists use when they suspect they are looking at something larger than the immediate hypothesis, characterized the changes as body-wide and consistent with broad anti-aging signatures. The methodology is worth pausing on

For patients with BMI 35 kg/m (regardless of comorbidities) or BMI 30-34.9 kg/m with metabolic disease, bariatric surgery consultation may be appropriate, according to 2022 American Society for Metabolic and Bariatric Surgery guidelines

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