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Description

Aaron Wenzel is a concierge physician specializing in the care of fast-moving entrepreneurs, executives, and public figures in the Nashville, TN area

Hormonal shifts during perimenopause and menopauseparticularly the drop in estrogen, progesterone, and DHEAcreate a cascade of changes in the body: Slower metabolism (especially after age 40) Increased insulin resistance Visceral fat accumulation (around the belly and midsection) Disrupted sleep and cortisol imbalance Loss of lean muscle mass This isnt just about appearance

While Zepbound isnt a replacement for every treatment plan, it offers an additional tool especially for patients struggling with weight and traditional therapies

Genetic biomarkers in GLP-1 and GLP-1R pathways may help provide context about individual predispositions in peptide sensitivity and metabolic response

Head-to-Head Trial: SUSTAIN 7 The most direct comparison comes from the SUSTAIN 7 trial, which directly compared semaglutide and dulaglutide: Study design: 1,201 patients with Type 2 diabetes Compared semaglutide 0.5mg vs