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Module 1 establishes this mechanistic case, defines the three levels of GLP-1 RA use, and introduces microdosing as a longevity lever: a targeted intervention that preserves muscle, reduces inflammation, and supports long-term metabolic health at doses well below standard therapeutic thresholds

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Current evidence quality : Most berberine studies are relatively small, short-term (typically 816 weeks), and conducted primarily in Asian populations, which may limit generalisability

Some patients may experience mild side effects, but these are generally well-tolerated

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This suggests that starting with lower doses and smaller dose increments is associated with a more favorable side effect profile