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Epac: a new cAMP-binding protein in support of glucagon-like peptide-1 receptor-mediated signal transduction in the pancreatic beta-cell

Diabetic Retinopathy: Diabetic retinopathy is a complication of diabetes where high blood sugar levels damage the retinas blood vessels

doi: 10.1007/s11695-014-1560-z 11 TsesmeliNCoumarosD

5 Pharmacological effects of GIP, GLP-1 and their mimetics The pharmacological benefits of GIP, GLP-1, and their synthetic mimetics arise from their pleiotropic effects, encompassing at least five key functions: bolstering insulin secretion and survival of pancreatic -cells and modulating glucagon release by the pancreatic -cells in response to glycemic levels, acting on the satiety center in brain, slowing gastric emptying, regulating lipid and glucose metabolism through effects on adipose tissue and liver, and reducing systemic blood pressure