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Preclinical research suggests GLP-1 receptor activation may reduce neuroinflammation, decrease amyloid-beta accumulation, enhance synaptic plasticity, and improve brain glucose metabolism

Yet, the actual risk of metformin-associated lactic acidosis (MALA) appears to be extremely rare (approximately 3 cases per 100,000 patient-years)

Scanning of the glucagon-like peptide-1 receptor localizes G protein-activating determinants primarily to the N terminus of the third intracellular loop

Yuan and a group of other researchers recently published a paper comparing the effectiveness of different GLP-1RAs

Rapid weight loss can contribute to changes in facial volume and skin laxity

The SURMOUNT-5 trial found approximately 20.2% average body-weight loss with branded tirzepatide versus 13.7% with branded semaglutide over 72 weeks in adults with obesity and without diabetes