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However, the risk for thyroid cancer was significantly higher within the first year after GLP-1RA initiation and was amplified in the overall as-treated analysis that censored patients when therapy was discontinued or another medication was added. The research team indicates this could be a sign that GLP-1 users are being screened for thyroid cancer at a higher rate than other diabetes drugs, resulting in a spike in diagnoses in the first year of taking the drug

With this degree of weight loss in only 48 weeks, we see people having improvement or resolution in other conditions like hypertension, hyperlipidemia, osteoarthritis, sleep apnea, and more weight-related conditions, Billings said

Evans says, if pregnancy is not desired, a backup birth control method is recommended

These results taken together suggest that adding even mild amounts of GR agonism (to increase energy expenditure) on top of a dual agonist like Tirzepatide is able to produce even more pronounced decreases in weight