dpp 4 inhibitors vs glp 1 agonist PDB-101: Diabetes Mellitus: Diabetes Mellitus: undefined: DPP4 Role of DPP-4 Inhibitors in

95% CI 1.70 to 8.45)

All findings to date derive from preclinical and early investigational data

Studies in mice suggest that GIP may potentiate the GLP-1-induced reduction of food intake and body weight by enhancing POMC expression and neuronal activation within distinct neuron populations in the hypothalamus (149)

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Emerging Role of Dual GLP-1 Receptor Agonists

More recently, dual GIP/GLP-1 RAs, such as tirzepatide, as well as emerging dual and triple incretin-based therapies, have demonstrated substantial efficacy in both glycaemic and weight control