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Browse all Peptides & GLP-1 education Medical and Editorial Standards Medical review process: This article was reviewed for medical accuracy, scientific clarity, evidence alignment, and appropriate discussion of genetics, medications, supplements, biomarkers, and health-related claims

Studies show that gastroparesis may be one of many significant risks associated with the use of GLP-1 drugs like Ozempic

Furthermore, the procedures the patients underwent are part of standard clinical practice and reflect good clinical care, with no additional interventions or experimental protocols beyond routine care

1 How it works The design of orforglipron emphasizes stability in the GI tract, which allows oral dosing while preserving target engagement

Key results at 80 weeks: Participants on the 4 mg dose lost an average of 47.2 lbs (19.0%) Participants on the 12 mg dose lost an average of 70.3 lbs (28.3%) 45.3% of participants on the 12 mg dose achieved at least 30% weight loss a level historically associated with bariatric surgery outcomes The 4 mg dose showed a lower rate of discontinuation due to adverse events than even placebo In a study extension to 104 weeks, participants with a starting BMI of 35 or higher who received 12 mg lost up to an average of 85.0 lbs (30.3%)