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Conclusions Semaglutide plays a positive role in alleviating -cell dysfunction by regulating gut microbiota, and METTL3/14, PDX-1, insulin signal pathway-related genes may be associated with CR.

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After reviewing several large epidemiological studies, clinical trial and in-market data, EMAs Pharmacovigilance Risk Assessment Committee has concluded non-anterior ischemic optic neuropathy is a very rare side effect of Ozempic, that may affect up to one in 10,000 people taking semaglutide.
