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It has been suggested that the endocrine system could play a role, especially the renin-angiotensin-aldosterone system (RAAS)

Overall, the research suggests that maintaining healthy sleep habits, consistent eating patterns and good gut health may help support normal GLP-1 secretion and improve metabolic health

However, these effects alone might not provide weight reduction, but they are said to be combined with a calorie- deficit diet and regular exercise to get results 1 , 3

History of pancreatitis, severe gastroparesis, or diabetic retinopathy (for patients with diabetes) requires careful consideration

In April 2024, researchers at the University Medical Centre Ljubljana in Slovenia conducted a study involving 25 women with PCOS and obesity

When food intake drops below 1,200-1,500 calories per day, it becomes nearly impossible to meet micronutrient needs through food alone