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But the same mechanisms that make these drugs effective can also cause gastrointestinal side effects such as: Nausea Vomiting Diarrhea Reduced appetite All of these symptoms can contribute to lower fluid intakeor increased fluid losswhich is a fast track to dehydration

After 52 weeks, participants who took 36 milligrams of orforglipron saw a key blood sugar marker reduce by nearly 2 percent, while those who received 14 milligrams of oral semaglutide saw levels drop by nearly 1.5 percent

Diabetic retinopathy and GLP-1 therapies

Key variants in genes such as GLP1R, GIPR, FTO, and MC4R predict how your body will respond to semaglutide and whether you might benefit from tailored dosing strategies or alternative compounds

STEP trial participants who reached the 2.4 milligram weekly dose lost an average of 22% of their body weight over 68 weeks, while lower-dose cohorts saw proportionally less dramatic results

"It was very worrisome," she said