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Heres what you need to know: Dont take tirzepatide (Mounjaro or Zepbound ) if you or anyone in your family has had: Medullary thyroid carcinoma (MTC) Multiple endocrine neoplasia syndrome type 2 (MEN 2) Also, avoid tirzepatide if youve previously had a serious allergic reaction to tirzepatide or any of its ingredients

It is also worth noting that our comparison with topiramate, which shares a weight loss property, may partly reflect topiramates poor real-world tolerability and compliance rather than a true pharmacological advantage of GLP1 RAs. However, he also stated that the overall signal is encouraging and justifies further investigation