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Whether this is a direct action of metformin on GLP-1 release, and whether some of the glucose-lowering effect of metformin occurs due to GLP-1 release, is unknown
GLP-1 medications reduce appetite substantially, which means you eat less overall
Formulation factors may also contribute to tolerability differences
Your body loses fluids faster when fighting infection, and reduced appetite from both COVID and semaglutide can make you forget to drink water, potentially worsening recovery
